This article discusses the link between OCBs and MS and what the testing involves. Examining CSF and serum in parallel for OCBs of IgG provides more diagnostic information than examining CSF alone, and the latter is potentially misleading. They will insert the thin needle between the two bones in the lower back and extract the sample. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMjA4Njk3Ni1vdmVydmlldw==. In addition, serum oligoclonal bands are present in some patients with Hodgkin's disease and in up to 5% of normal individuals. All rights reserved. The presence of no oligoclonal bands or one band is normal. Share cases and questions with Physicians on Medscape consult. We avoid using tertiary references. Summary Oligoclonal bands (OCBs) are a type of protein that occurs in the cerebrospinal fluid (CSF). Note: Normal value ranges may vary slightly among different laboratories. A. This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Increased intrathecal Ig synthesis may occur in other inflammatory CSF diseases and, therefore this assay is not specific for MS. CSF Oligoclonal Bands Interpretation: <2 bands. The site is secure. Clin Chem Lab Med. Similarly, if a test comes back negative but a person is experiencing symptoms, additional tests may be necessary to confirm what is causing the symptoms. Pathology. The Consortium of Multiple Sclerosis Centers has endorsed IEF because of its increased sensitivity (>95%). Pathology. Multiple Myeloma. CSF Oligoclonal Bands Interpretation: <2 bands, mml-Behavioral, mml-Epilepsy, mml-Movement-Disorders, mml-Demyelinating-Diseases, mml-Neuroimmunology, mml-Neuromuscular, mml-Autonomic, mml-Neuro-oncology, mml-Pediatric, mml-Pain, mml-Spinal-Cord, mml-Neuro-ophthalmology. Long-lasting double vision Slurred speech Bowel or bladder problems Dizziness Fatigue Other reasons your physician may request a CSF oligoclonal banding test are to identify if other serious. Diagnosis of multiple sclerosis; especially useful in patients with equivocal clinical presentation and radiological findings, Isoelectric Focusing (IEF) with IgG Immunoblot Detection. StatPearls. Ronald Hoffman, Leslie E. Silberstein, Sanford J. Shattil, Bruce Furie, Philip McGlave. How Viagra became a new 'tool' for young men, Ankylosing Spondylitis Pain: Fact or Fiction, Multiple Sclerosis Association of America, https://www.nationalmssociety.org/Symptoms-Diagnosis/Diagnosing-Tools/Cerebrospinal-Fluid-(CSF), https://www.frontiersin.org/articles/10.3389/fimmu.2019.00726/full, https://www.nationalmssociety.org/Symptoms-Diagnosis/Diagnosing-MS, https://www.nhs.uk/conditions/lumbar-puncture/, https://www.hopkinsmedicine.org/health/treatment-tests-and-therapies/lumbar-puncture. You are wondering about the question what conditions show oligoclonal bands in csf and serum but currently there is no answer, so let kienthuctudonghoa.com summarize and list the top articles with the question. 2005 - 2023 WebMD LLC. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Zeman A, McLean B, Keir G, Luxton R, Sharief M, Thompson E. J Neurol Neurosurg Psychiatry. A comparison of systemic sclerosis and multiple sclerosis, Multiple sclerosis: 5 things to know about MS, Relapsing-remitting multiple sclerosis (MS), What to know about late onset multiple sclerosis, at least two areas of damage to, or lesions in, the brain or spinal cord, evidence that the damage occurred at different times, evidence that another disease has not caused the damage to the CNS. However, medical risks exist, including: People usually have discomfort during and shortly after the test. What specimens can be used to perform an immunofixation test? [18, 19], Detection of a paraprotein by immunofixation is possible in lymphomas. This pattern represents the presence of polyclonal immunoglobulin. Learn more here. The oligoclonal band (OCB) assay requires paired cerebrospinal fluid (CSF) and serum samples. Consensus recommendations for standard investigative workup: report of the International Myeloma Workshop Consensus Panel. What is Oligoclonal Bands Cerebrospinal Fluid (CSF)andSerum test? If the CSF protein concentration is >200 mg/dL, even high immunoglobulin production in the central nervous system can be obscured by the presence of plasma proteins. During the procedure, a person will lie on their side with their legs pulled up toward their chin and their chin tucked in. [2] : Monoclonal gammopathy of undetermined significance (MGUS) Our website services, content, and products are for informational purposes only. Oligoclonal bands: An immunological and clinical approach. Oligoclonal Bands . Elsevier; 2015:chap 18). Beaumont-Epinette MP, Moreau C, Besnard S, Latute F, Collet N, Sebillot M, et al. Disclaimer. These findings, however, are not specific for MS as CSF-specific IgG synthesis may also be found in patients with other neurologic diseases including infectious, inflammatory, cerebrovascular, and paraneoplastic disorders. [Full Text]. eCollection 2020 Jan-Mar. Sin categorizar; what conditions show oligoclonal bands in csf and serum? 7th ed. However, technical issues including blot, staining, and IEF reproducibility as well as operator-dependent pattern interpretations decrease reproducibility, causing misinterpretations of results, with significant diagnostic implications. 2020 Jan 22;6(1):2055217319901291. doi: 10.1177/2055217319901291. Local CNS synthesis implies local CNS disease, especially multiple sclerosis but sometimes other CNS inflammation, infection or neoplasia. Immunofixation consists of an electrophoresis phase and a fixation phase. Leukemia. What is the reference range of an immunofixation test? A doctor may use a CSF oligoclonal banding test to help confirm MS, but they will also need to consider other diagnostic criteria. The assay uses reagents from Helena Laboratories. The monoclonal band of immunoglobulin indicates a neoplastic process like multiple myeloma and Waldenstrom's macroglobulinemia. The CSF oligoclonal band screen looks for these bands in your CSF. The .gov means its official. Saadeh R, Pittock S, Bryant S, et al: CSF kappa free light chains as a potential quantitative alternative to oligoclonal bands in multiple sclerosis. Saadeh R, Pittock S, Bryant S, et al: CSF kappa free light chains as a potential quantitative alternative to oligoclonal bands in multiple sclerosis. The detection of increased intrathecal immunoglobulin synthesis is the basis for current diagnostic laboratory tests for MS. Oligoclonal bands (OCBs) are a type of protein that occurs in the cerebrospinal fluid (CSF). On the contrary, a persistent monoclonal protein despite treatment is a sign of refractory disease. Oligoclonal bands. Healthline Media does not provide medical advice, diagnosis, or treatment. John C Leighton, Jr, MD, FACP is a member of the following medical societies: American College of Physicians, American Medical Association, American Society of Hematology, American Society of Clinical OncologyDisclosure: Nothing to disclose. Background Meningoencephalitis of unknown origin (MUO) is an inflammatory disease of the canine central nervous system (CNS) that shares several features with multiple sclerosis (MS) in humans. 2018 Feb;17(2):162-173, 4. [QxMD MEDLINE Link]. Using optimized, standardized methodology, preferentially protein separation by isoelectric focusing followed by immunoblotting, more than 95% of patients with . Adv Clin Chem. Inicio; what conditions show oligoclonal bands in csf and serum? The https:// ensures that you are connecting to the Bethesda, MD 20894, Web Policies J Neurol Neurosurg Psychiatry. [9], Surveillance among patients with MGUS or smoldering (asymptomatic) multiple myeloma, Immunofixation of the urine and serum should be included in a battery of tests after 2-3 months following diagnosis of smoldering myeloma, then every 4-6 months for 1 year, and, finally, every 6-12 months if the results are stable. The separated immunoglobulins (Ig) are visualized by an IgG immunoblot, and OCBs that are present in the CSF and not in the serum are reported. Oligoclonal bands in CSF have been reported in cases of neurosyphilis, acute bacterial or viral meningitis, progressive multifocal leukoencephalopathy, subacute sclerosing panencephalitis, progressive rubella panencephalitis, polyneuritis, optic neuritis, trypanosomiasis, and other infectious or autoimmune diseases. How is an Oligoclonal Bands CSF and Serum test performed? Monoclonal gammopathies of undetermined significance. If the test comes back positive for OCB levels, but a doctor cannot diagnose MS, they will likely order further testing to determine the underlying cause of the elevated OCB levels. When Do You Need a CSF Oligoclonal Banding? [10, 17], A 24-hour concentrated urine sample is appropriate for urine immunofixation. official website and that any information you provide is encrypted [Full Text]. (2016). The presence of multiple bands indicates that something is wrong. Therefore, such an approach cannot be currently recommended. A polyclonal immunoglobulin pattern in the serum . (n.d.) Retrieved from. Gurtner KM, Shosha E, Bryant SC, et al: CSF free light chain identification of demyelinating disease: comparison with oligoclonal banding and other CSF indexes. Youll need to change into a hospital gown with the back open. 2019 Jan. [QxMD MEDLINE Link]. answer the question what conditions show oligoclonal bands in csf and serum, which will help you get the most accurate answer. Oligoclonal bands are found in up to 95 percent of patients with clinically definite MS . Am J Clin Pathol. Both serum and spinal fluid are required. When the oligoclonal band assay detects 2 or more unique IgG bands in the cerebrospinal fluid (CSF), the result is positive. 2019 April 09; 2019:92, The oligoclonal band (OCB) assay requires paired cerebrospinal fluid (CSF) and serum samples. When is an immunofixation test indicated? In addition, when protein electrophoresis assays are positive for a monoclonal protein, serum and urine immunofixation are indicated for the appropriate identification of the immunoglobulin and the corresponding light chain. 135:1048-51. The site is secure. When the oligoclonal band assay detects 2 or more unique IgG bands in the cerebrospinal fluid (CSF), the result is positive. There are various ways a person can manage spasticity. Additionally, your symptoms could be due to injury to a nerve, pressure on spinal or peripheral nerves (neuropathy), vitamin deficiency, lack of blood supply due to cholesterol plaque from atherosclerosis in the extremities, viral infection and use of certain medications. Bird J, Behrens J, Westin J, et al. EJIFCC. 1. CSF immunofixation that does not reveal oligoclonal bands is also considered normal. Oligoclonal bands: An immunological and clinical approach. 133 (25):2664-8. Ann Clin Biochem 1990;27:436-443; Hortin GL: Amino Acids, Peptides, and Proteins. Oligoclonal bands are multiple distinct bands in the zone of the CSF pattern that are not present in serum. Detection of oligoclonal bands in cerebrospinal fluid by immunofixation electrophoresis. oligoclonal bands: Immunoglobulins found in the cerebrospinal fluid of patients with multiple sclerosis (MS) and, occasionally, in other neurological conditions. You should expect to rest for at least an hour after your test. An official website of the United States government. Oligoclonal bands and antibody responses in multiple sclerosis, The frequency of CSF oligoclonal banding in multiple sclerosis increases with latitude, Diagnostic Tests for Neurological Disorders, Cerebrospinal fluid in multiple sclerosis, Tests for Brain, Spinal Cord, and Nerve Disorders, A Manual of Laboratory and Diagnostic Tests, Preventing Deaths from Cryptococcal Meningitis, Subacute Sclerosing Panencephalitis Information Page, Stiffness and muscle spasms that may occur in any limb but are more common in the legs. IgA or IgM bands are less common. Paired serum and cerebrospinal fluid (CSF) samples were collected for diagnostic purposes after informed consent was obtained. Lumbar puncture is widely used and considered safe. Epub 2019 Dec 2. Clin Drug Investig. PMC -, Arch Neurol. Arch Pathol Lab Med. Federal government websites often end in .gov or .mil. John C Leighton, Jr, MD, FACP Clinical Associate Professor, Jefferson Medical College of Thomas Jefferson University; Chief, Division of Medical Oncology, Jeanes Hospital; Associate Director, Associate Chief, Divisions of Hematology/Medical Oncology, Albert Einstein Cancer Center; Associate Member Kimmel Cancer Center, Thomas Jefferson Hospital MeSH Lancet Neurol. Your doctor may order this test if he/she suspects that you have multiple sclerosis. But it can also be used to treat disorders that cause overactive muscles or pain. A concomitant measurement of the creatinine in the 24-hour urine sample for correction of sampling errors has been proposed. Some common symptoms of multiple sclerosis are: Some of the less common symptoms include: Doctors may also order this test to diagnose other neurological diseases and inflammatory conditions like: Give your healthcare provider complete information about all the medicines you are consuming. Front Neurol. [11] HIV-related encephalitis, neurosyphilis, Lyme meningoencephalitis, neurosarcoidosis, acute disseminated encephalomyelitis (ADEM), systemic lupus erythematosus (SLE), Sjgren syndrome, subacute sclerosing panencephalitis, CNS malignancy, neuromyelitis optica, and transverse myelitis can all reveal oligoclonal banding in CSF immunofixation, precluding the use of immunofixation for the detection of oligoclonal bands as a sole diagnostic technique in multiple sclerosis. disease who have positive oligoclonal bands have a higher risk of evolution to MS . Again, the lanes are broad and the transition to the lane borders is smooth. What are considerations regarding immunofixation results in multiple myeloma, and what are the limitations of a 24-hour concentrated urine sample for immunofixation testing? [1] In the former, the serum is applied to an agarose gel, and the negatively charged serum proteins move toward the cathode under the influence of an electric current. The presence of these bands implies inflammation in the central nervous system (CNS) which may be caused by an infection or a disease. [QxMD MEDLINE Link]. For assistance, contact. In order to confirm local production of oligoclonal IgG in CSF, a matched serum sample is required. If your work is strenuous and might involve your back, tell your doctor. Last medically reviewed on June 15, 2016, A cerebrospinal fluid (CSF) test can be used to diagnose many conditions, from neurological disorders to infectious diseases. Follow-up of multiple myeloma, Waldenstrom macroglobulinemia, and AL amyloidosis, Immunofixation of urine and serum samples should be performed in all patients with multiple myeloma, Waldenstrom macroglobulinemia, and AL amyloidosis every 3 months after the completion of treatment in order to evaluate for response or to document a relapse. National Library of Medicine Subsequent immunofixation with electrophoresis identified the monoclonal protein as an IgG antibody (paraprotein) with a lambda light chain (arrow). [ 1] Serum or urine immunofixation negative for a monoclonal protein or a polyclonal pattern is considered to be normal. Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics. J Neurol Neurosurg Psychiatry. If you log out, you will be required to enter your username and password the next time you visit. Other inflammatory conditions of the CNS can present with oligoclonal bands in CSF resulting from intrathecal production of antibodies. MNT is the registered trade mark of Healthline Media. Dimopoulos M, Kyle R, Fermand JP, et al. How is a serum sample collected for an immunofixation test? 2003 Nov:120(5):672-675, 3. This website also contains material copyrighted by 3rd parties. Twenty-four-hour Bence-Jones protein determinations: can we ensure accuracy?. Bethesda, MD 20894, Web Policies Side effects may occur from mAbs treatment including rash, diarrhea, nausea, dizziness and pruritis (itchy skin). government site. Guido Tricot. 24:1121-7. [20]. Autoimmune disorders. Geraint Fuller MA MD FRCP, Mark Manford BSc MBBS MD FRCP, in Neurology (Third Edition), 2010. Learn more about the, Medical News Today has strict sourcing guidelines and draws only from peer-reviewed studies, academic research institutions, and medical journals and associations. The diagnosis of multiple sclerosis (MS) is dependent on clinical, radiological, and laboratory findings. They will remove the needle and apply a dressing. Mayo Clinic. Ramakrishnan N, Jialal I. Bence-Jones Protein. The presence of more than one band is an indicator of illness. Their presence suggests inflammation of the central nervous system due to infection or another disease. CSF is used in the diagnosis of multiple sclerosis (MS) by identifying increased intrathecal IgG synthesis qualitatively (oligoclonal bands). The test alone is not enough to diagnose MS. A doctor must also find: The CSF oligoclonal banding screening involves undergoing a procedure called a lumbar puncture. The samples were stored at -40C until oligoclonal band testing was performed. CSF is a clear, colourless fluid found in your CNS. Abstracts of Presentations at the Association of Clinical Scientists 143. Amato, A. Clinical correlation recommended. This article reviews all you need to, Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. Would you like email updates of new search results? Clinical correlation recommended. Oligoclonal bands (OCBs) are bands of immunoglobulins that are seen when a patient's blood serum, or cerebrospinal fluid (CSF) is analyzed. The detection of increased intrathecal immunoglobulin synthesis is the basis for current diagnostic laboratory tests for MS. The separated immunoglobulins (Ig) are visualized by an IgG immunoblot, and OCBs that are present in the CSF and not in the serum are reported. 1. Clipboard, Search History, and several other advanced features are temporarily unavailable. Disclaimer. Sample: Serum (whole blood or plasma is inappropriate, as fibrinogen may alter the results), Sample: 24-hour urine collection, concentrated. A local anaesthetic is used for the short procedure. brain herniation if a brain mass is present. Both serum and spinal fluid are required. However, the presence of oligoclonal bands does not necessarily confirm the diagnosis, as other conditions can present with oligoclonal bands in the CSF. Can diet help improve depression symptoms? Cerebrospinal fluid (CSF) and serum, collected at the same time, 0.5 mL cerebrospinal fluid (CSF) and 0.5 mL serum, Red-top tube or gel-barrier tube and plastic (CSF) tube, Plasma instead of serum specimen (since fibrinogen band may obscure the electrophoretic zone); serum and CSF not collected within eight hours of each other, Diagnose diseases of the central nervous system including meningitis, tumor, syphilis, and multiple sclerosis, Isoelectric focusing (IEF) and immunoblotting on agarose gel. When abnormal results are reported back to your physician, further medical investigations can pursue the cause for the increased presence of immunoglobulin proteins in your cerebrospinal fluid. To detect OCB levels, a doctor may order a CSF oligoclonal banding test, which requires a sample of the CSF. Oligoclonal bands are visible as an increased concentration of restricted bands of IgG after isoelectric focusing and immunofixation of IgG. It sounds that these OGB's may be due to demyelination of brain tissues. CSF is used in the diagnosis of multiple sclerosis (MS) by identifying increased intrathecal IgG synthesis qualitatively (oligoclonal bands). The diagnostic process will also involve the doctor: If elevated OCB levels are present but a person does not fit the criteria for MS, a doctor will likely continue to search for the underlying cause. However, there are other possible causes of elevated OCB levels. The person conducting the test will clean and cover the puncture. Most of the clinical interest in CSF electrophoresis is focused on the region. doi: 10.1136/bcr-2020-234316. According to Mayo Medical Laboratories, this screen is positive in 70 to 80 percent of MS patients. Abnormal CSF OCB patterns have been reported in 70% to 80% of MS patients. This test involves a lumbar puncture, or spinal tap, which takes place at a hospital or clinic. In a cohort of 1307 patients analyzed in 2018, where 159 had demyelinating disease, the Mayo Clinic oligoclonal banding test had a clinical sensitivity of 74% and clinical specificity of 89%, with a ROC AUC of 0.813 when 2 or more unique cerebrospinal fluid bands are used as a cutoff for positive. UK Myeloma Forum (UKMF) and Nordic Myeloma Study Group (NMSG): guidelines for the investigation of newly detected M-proteins and the management of monoclonal gammopathy of undetermined significance (MGUS). It may be used during spinal. Griggs R. C., Jozefowicz R. F., Aminoff M. J. The presence of oligoclonal bands in CSF but not in the serum, given their intrathecal production, is helpful in the diagnosis of multiple sclerosis. 1998. Unauthorized use of these marks is strictly prohibited. They can also use it to diagnose other inflammatory conditions and neurological diseases. Diagnosis of multiple sclerosis; especially useful in patients with equivocal clinical presentation and radiological findings. Before The presence of 2 or more unique CSF oligoclonal bands was . Am J Clin Pathol. We link primary sources including studies, scientific references, and statistics within each article and also list them in the resources section at the bottom of our articles. Serum and CSF IgG concentrations were analyzed in a nephelometer (BNII; Behring, Marburg, Germany). The oligoclonal band pattern is blurred when a concomitant inflammatory response causes increased protein leakage of plasma proteins into the CSF. The significance of serum oligoclonal bands in neurological diseases. Eric B Staros, MD Associate Professor of Pathology, St Louis University School of Medicine; Director of Clinical Laboratories, Director of Cytopathology, Department of Pathology, St Louis University Hospital 11 (2):24. 2012 Apr;44(3):248-50. doi: 10.1097/PAT.0b013e3283511a87. The identification of a monoclonal immunoglobulin is helpful in the diagnosis of the following conditions How is a urine sample collected for an immunofixation test? The results show that the individual MS patient had oligoclonal IgG bands in serum, differ with respect to number, isoelectric point and L chain type from the oligoclonal IgG profile seen in the patient's CSF. 2010. The doctor or nurse will then perform the following steps: Lab technicians will then analyze the CSF sample for OCBs. To determine the diagnostic significance of serum OCBs 146 patients with serum OCBs were identified among 1874 patients with suspected neurological disorders (7.6%). People who receive a diagnosis of MS typically have positive test results, indicating that OCB is present in the CSF. A serum sample is taken at the time of the lumbar puncture as oligoclonal bands may be present in CSF alone or CSF and blood. Immunofixation in CSF for the detection of oligoclonal bands is indicated every time there is suspicion for multiple sclerosis. Therefore, the International Myeloma Working Group Mass Spectrometry Committee created a set of recommendations for the evaluation of monoclonal proteins in multiple myeloma and related disorders, using mass spectrometry. PLoS One. 8600 Rockville Pike Blood. 1993 Jan;56(1):32-5. doi: 10.1136/jnnp.56.1.32. Lahuerta JJ, Jimenez-Ubieto A, Paiva B, et al. Blood. One or no oligoclonal bands in the CSF is considered normal. 9 (5):1895-1900. Northwestern University researchers think so. Laboratory findings, including CSF cell count, CSF protein concentration, the quotient of albumin (Qalb), IgG index, and the percentage with positive oligoclonal IgG bands, and baseline treatment . Diagnostics (Basel). 2011. Oligoclonal bands If present in both, they may represent systemic infection, autoimmune disease, sarcoidosis or neoplasia. A doctor will insert a needle through the skin and into the spine. The oligoclonal band (OCB) assay requires paired cerebrospinal fluid (CSF) and serum samples. We herein review central and peripheral nervous system conditions associated with OCBs and discuss their relation with pathogenetic mechanisms. Immunoglobulin-related amyloidosis. Shah D, Seiter K. Multiple myeloma. A., & Russell, J. In this case, the IgM lane, which is normally absent, is broad with smooth borders. Your doctor will read them and discuss the next steps. 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Bands present only in the CSF indicate local CNS disorders, especially multiple sclerosis, and sometimes other conditions such as CNS infection, inflammation or neoplasia (tumours or cancers). The presence of 2 or more unique CSF oligoclonal bands was reintroduced as one . Before the test, a doctor may order imaging tests, such as a CT scan or an MRI scan, to ensure that it is safe for the person to undergo the procedure. Careers. All Rights Reserved. Geraint Fuller MA MD FRCP, Mark Manford BSc MBBS MD FRCP, in Neurology (Third Edition), 2010. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Pathol Biol (Paris). Discuss with your healthcare provider any symptoms you are experiencing after treatment. Oligoclonal bands. Multiple sclerosis is a CNS disorder in which the immune system damages myelin (a protective sheath around nerves), the nerves and the cells that produce myelin. See also: band 19952023 Mayo Foundation for Medical Education and Research. Collection Instructions: Label specimen as spinal fluid. The diagnosis of multiple sclerosis (MS) is dependent on clinical, radiological, and laboratory findings. Centers for Disease Control and Prevention: Systemic Lupus Erythematosus (SLE)., Cerebrospinal Fluid Research: The regulation of brain states by neuroactive substances distributed via the cerebrospinal fluid; a review., Cleveland Clinic: Cerebrospinal Fluid (CSF) Leak., HHS Author Manuscripts: Central Nervous System Agents for Ischemic Stroke: Neuroprotection Mechanisms., JAMA Neurology: Oligoclonal Band Number as a Marker for Prognosis in Multiple Sclerosis., Johns Hopkins Medicine: Neurological Complications of HIV., Mayo Clinic: Multiple sclerosis., Oligoclonal Banding, Serum and Spinal Fluid., Multiple Sclerosis Trust: Lumbar puncture., National Multiple Sclerosis Society: Cerebrospinal Fluid (CSF)., New Medical Life Sciences: What is the Nervous System?, University of California San Francisco Health: Medical Tests CSF oligoclonal banding.. This should go away within 24 hours. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. Damage to your spinal cord if you move during the procedure, Cerebral infarction (death of brain tissue due to insufficient blood flow), Idiopathic polyneuritis (inflammation of multiple nerves without an obvious cause), Cryptococcal meningitis (infection in the brain due to Cryptococcus fungus), Subacute sclerosing panencephalitis (a slowly progressive neurological disorder caused by measles virus), Progressive rubella panencephalitis (a neurological condition caused by rubella virus). Matos AMB, Dahy FE, de Moura JVL, Marcusso RMN, Gomes ABF, Carvalho FMM, Fernandes GBP, Felix AC, Smid J, Vidal JE, Frota NAF, Casseb J, Easton A, Solomon T, Witkin SS, Malta Romano C, de Oliveira ACP; NeuroCovBR Study Group.
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